A Mouse Study Unravels the Mystery of Overeating

(Newswire.net — November 29, 2022) Orlando, FL — Overeating has long been identified to be one of the underlying causes of obesity, which is a growing epidemic worldwide.

Researchers from The Stuber Lab at the University of Washington School of Medicine have shown that certain cells actually light up in obese mice. Further, they have been found to prevent signals indicating satiety. 

The findings of this research were published in the Neuron journal. 

The study reports on the function of glutamatergic neurons in mice. It is worth noting that these cells are found in the lateral hypothalamic area of the brain, which is a hub that regulates motivated behaviors, like feeding.

Investigators found that these neurons actually communicate to two different brain regions, one of which is the lateral habenula, which is a key brain region in the pathophysiology of depression. The other is called the ventral tegmental area, which is known best for the major role it plays in motivation, reward, and addiction.

“We found these cells are not a monolithic group, and that different flavors of these cells do different things,” said Stuber, a joint UW professor of anesthesiology and pain medicine and pharmacology. 

Stuber works at the UW Center for the Neurobiology of Addiction, Pain, and Emotion, and was the paper’s senior author. Mark Rossi, the acting instructor of anesthesiology and pain medicine, is the lead author.

The Stuber Lad looks into the function of major cell groups in the reward circuit of the brain. It also characterizes their role not just in addiction but also in mental illness, and this is in an effort to find treatments. 

The findings indicated that brain circuits that manage to feed at least partially overlap with brain circuitry that is involved in drug addiction.

Overeating is undeniably one of the culprits of obesity or weight gain. This is why it is important to take the measures useful in making eating behavior modifications. It is similarly important to engage in regular exercise.

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