A Study Has Shown RA Pain May Be Caused By Antibodies

(Newswire.net — August 24, 2022) Orlando, FL — Rheumatoid arthritis is undeniably prevalent, and is even the second most common type of arthritis in the U.S. Pain is a major symptom of this condition, and is a symptom being widely studied by researchers.

A study was carried out and published in the Journal of Experimental Medicine. 

In this research, it has been found that antibodies found in the joints before RA onset can produce pain even in the absence of arthritis. 

This study was carried out by Karolinska Institutet in Sweden report. 

The findings of this research may represent a general mechanism in autoimmunity. They may also facilitate the creation of new ways in lessening non-inflammatory pain produced by rheumatoid arthritis and other autoimmune diseases.

According to Camilla Svensson, we all know that inflammation is painful.

Svensson is a professor at the Department of Physiology and Pharmacology, Karolinska Institutet. 

“But pain can appear before any sign of inflammation in the joints and can remain a problem after it has healed. Our aim was to find possible mechanisms to explain that,” she adds.

This autoimmune disease called rheumatoid arthritis occurs when immune cells attack the cartilage and bone of the joints. It is worth noting that in Sweden, it affects roughly one percent of the population. 

Joint pain is a common early symptom, but even before it happens, the body beforehand produces immune antibodies against proteins in the joint. 

The investigators look into how the antibodies generate pain. In this study involving mouse subjects, the researchers injected cartilage-binding autoantibodies into the subjects.

They found that through the injection, the mouse subjects turned more sensitive to pain even before they could notice any signs of inflammation in the joints. It is also important to note that certain antibodies induced pain-like behavior in mice, and this suggests increased pain sensitivity in the joints. 

These antibodies had been designed not to activate immune cells and trigger inflammation.

Scientists continue to carry out studies to investigate the various aspects of rheumatoid arthritis. These include the effectiveness of certain all-natural remedies like curcumin, which has strong anti-inflammatory and antioxidant effects.

Curcumin has long been studied due to its disease-fighting benefits. Many studies have shown that its use could reduce severity of pain and improve physical limitations in those with arthritis. This is due to the anti-inflammatory benefits it offers.

In taking advantage of its arthritis-fighting benefits, it is wise to take into account the use of Divine Bounty Curcumin (http://amazon.com/Turmeric-Curcumin-BioPerine-Pepper-Extract/dp/B00VSVKJ8I).