Research Highlights New Technique Against Osteoporosis

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( — November 2, 2022) Orlando, FL — Hundreds of millions of people around the globe suffer from osteoporosis, which is the most common age-related bone disease. 

It has been found to affect one in three women and one in 5 men over the age of 50 years who suffer from osteoporotic bone fractures. It is worth noting that this condition called osteoporosis develops due to the excessive activity of bone-resorbing cells while there is a reduction in the activity of bone-forming cells.

A majority of current therapies for osteoporosis include the use of bisphosphonates, which work by blocking the activity of bone-resorbing cells. 

This prevents excessive bone resorption. However, it is important to be warned prolonged treatment of these medications eliminates the required bone turnover, which leads to increased fracture risk and other unwanted side effects. 

This is why it is important to develop new techniques in overcoming the limitations of these current treatments. A study was carried out to develop this new progress.

They were developed in cooperation with Professors Christoph Winkler (Department of Biological Sciences, National University of Singapore, NUS) and Manfred Schartl (Biocenter, Julius-Maximilians-Universität Würzburg, JMU, Germany). The findings were published in the journal PNAS.

In this genetic analysis in a small laboratory fish model, the investigating team was able to identify a small protein, the chemokine CXCL9. It is worth noting that under osteoporotic conditions, this small protein diffuses towards reservoirs, which hold bone-resorbing cell precursors. 

The precursors produced on their cell surface are called CXCR3. It is worth keeping in mind that both 

CXCL9 and its receptor CXCR3 have long been identified to modulate immune cell migration to inflammation sites.

“The new strategy allows a fine-tuned modulation of osteoclast numbers that are recruited to bone matrix rather than a widespread blockage of osteoclast activity as in traditional therapies,” said professors Schartl and Winkler. 

More studies are still underway to look into the various aspects of bone health. Over the years, researchers have been investigating the impacts of taking some nutrients like B vitamins protective to the bones.

Years of research have shown that the intake of B vitamins is associated with a myriad of health benefits. It is worth keeping in mind that inadequate levels of these nutrients may result in negative health outcomes. 

Divine Bounty B Vitamin Complex could be helpful for bone health and protection. This amazing formula has Choline, Pantothenic acid, Biotin, Vitamin B12, Folic Acid, Niacin, Riboflavin, Thiamin, and vitamin B6. (

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