Scientists Discuss Treatment That May Reverse Antibiotic Resistance

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( — November 18, 2022) Orlando, FL — Antibiotic resistance rates continue to soar and even claim the lives of over 30,000 people annually in the U.S.

Interestingly, a study has discovered a new possible treatment with the ability to reverse antibiotic resistance in bacteria, which causes certain conditions like pneumonia, sepsis, and urinary tract infections (UTIs).  

This highly collaborative research was conducted by scientists from the Ineos Oxford Institute (IOI) for Antimicrobial Research at the University of Oxford and several institutions across Europe. 

Its findings were published in Nature Chemistry. 

Further, it was funded by the Innovative Medicines Initiative (IMI) through the European Lead Factory (ELF) and the European Gram-Negative Antibacterial Engine (ENABLE) programs.

According to experts, carbapenems like meropenem, pertain to a group of antibiotics that are vital yet the last resorted-to used in the treatment of serious, multi-drug resistant infections in cases of failure of other antibiotics, such as penicillin.

However, some bacteria have actually found a way to survive treatment with carbapenems. This was through the production of certain enzymes called Metallo-beta-lactamases (MBLs), which break down the carbapenem antibiotics, halting their work.

In this research, the investigators first screened hundreds of thousands of chemicals in an effort to see which would tightly attach to MBLs to stop them from working. It is worth noting that they did not react with any human proteins.

The research has led to the discovery of indole carboxylates as promising new candidates. 

The World Health Organization (WHO) warns there is an estimated  10 million deaths every year due to antimicrobial resistance by 2050.

 “An increase in antimicrobial resistance is absolutely inevitable. It is a massive problem because collectively we haven’t been making enough new clinically useful antibiotics,” said Professor Christopher Schofield, Academic Lead (Chemistry), Ineos Oxford Institute at the University of Oxford, said.

“As a society, we must find ways both to make new antibiotics and protect the ones we have. The alternative is that routine modern medicine will be disrupted in a manner simply too horrendous to conceive.”

Fighting antibiotic resistance may necessitate a decrease in the rates of urinary tract infections, a type of infection usually treated through the use of antibiotics. It is worth realizing that antibiotic misuse or overuse causes antibiotic resistance. In battling with UTIs, it may be best to consider the use of a therapeutic sugar called D-mannose.  

When it comes to obtaining the benefits of using this scientifically-tested ingredient, it may be helpful to take into account the use of Divine Bounty D-mannose. 

This formula is made in an FDA-inspected facility in the U.S. and is believed to be superior to other brands. It is loaded with scientifically-tested ingredients and even comes with a customer satisfaction guarantee. (

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