Research Shows Relevance of Age and Sex on Time-Restricted Diet

(Newswire.net — November 22, 2022) Orlando, FL — Scientists have been carrying out studies to look into various eating patterns and their impacts on weight loss.

A study has particularly shown that age and sex play a role in the benefits that time-restricted eating produces. It is worth noting that this dietary regimen called time-restricted eating (TRE) restricts eating to specific hours and has been garnering increasing interest in weight-loss circles.

The research, which was carried out by Salk scientists, was published in Cell Reports. 

While a majority of TRE studies focus on weight loss in young male mice, the Salk scientists aimed at determining whether TRE confers additional advantages on other populations.  

Researchers say that while sex and age do impact TRE outcomes, such an eating strategy produces multiple health benefits for young and old of both sexes. This indicates that TRE may actually be a valuable intervention for fatty liver disease, type 2 diabetes, and liver cancer, as well as infectious diseases such as COVID-19, in humans. 

“For many TRE clinical interventions, the primary outcome is weight loss, but we’ve found that TRE is good not only for metabolic disease but also for increased resilience against infectious diseases and insulin resistance,” says Satchidananda Panda.

Panda is a professor in Salk’s Regulatory Biology Laboratory and holder of the Rita and Richard Atkinson Chair.

After analyzing the tissues of mice on TRE for the purpose of ascertaining their chemical makeup and processes, the investigators found that TRE, regardless of sex, age, or weight loss profile, strongly protected against fatty liver disease.

It is worth noting that such a condition happens to 100 million Americans and no medicine has been approved for it.

“This was our first time studying female mice, and we weren’t sure what to expect,” says first author Amandine Chaix, a former staff scientist in the Panda lab and now an assistant professor at the University of Utah. 

“We were surprised to find that, although the females on TRE were not protected from weight gain, they still showed metabolic benefits, including less-fatty livers and better-controlled blood sugar.” 

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