Research Highlights Effectiveness of Antibiotic Resistant Ointment

(Newswire.net — November 24, 2022) Orlando, FL — Antibiotic resistance continues to be a rapidly growing global health threat today. Experts are increasingly looking into this issue and finding some remedies helpful against the problem.

Scientists from the University of Cincinnati College of Medicine have shown that the use of AB569 promotes the death of antibiotic-resistant bacteria. It is worth noting that AB569 is a combination of acidified nitrite and EDTA (or ethylenediaminetetraacetic acid).

The study has also revealed that it enhances the healing of wounds in a variety of burn injuries. The findings of this interesting research were published in the journal Infection and Immunity. In 2018, the AB569 was patented in the U.S. by Daniel Hassett, Ph.D., professor in the Department of Molecular Genetics, Biochemistry and Microbiology at the UC College of Medicine. 

Hassett’s study has particularly revealed that AB569 kills virtually all pathogenic bacteria tested without observed acquired resistance. 

The Centers for Disease Control and Prevention Reveals that these, which include multi-drug resistant Pseudomonas aeruginosa (MDR-PA), are some of the most serious pathogens. Further, it exhibits multi-drug resistance and improved virulence properties.

“Multi-drug resistant bacteria, often called ‘superbugs,’ are an ever-burgeoning global health problem,” says Hassett. 

“As a result, there is a critical need to develop novel and effective antimicrobials for the prevention, treatment and eradication, and healing of such wounds that are complicated by the most formidable pathogen of burn patients, known as MDR-PA. Injury severity is predominantly due to potentially lethal sepsis caused by MDR-PA.”

The research has shown that AB569 synergistically acts to kill all human burn wound strains of the pathogen in vitro.

“AB569 not only kills the bug, but it also enhances the wound-healing process,” says Hassett.

Hassett is the co-corresponding author on this study with Latha Satish, Ph.D., director of clinical lab operations at Cincinnati Children’s Hospital Medical Center.

“At the same time, AB569 topical application significantly increases the anti-inflammatory mediators…that allow improved epidermal restoration and the healing process to occur more rapidly and efficiently.”

The scientific community scrambles to find techniques significantly helpful for lessening antibiotic resistance. Some study findings have revealed that lessening UTI rates may help, and the use of a therapeutic sugar called D-mannose may play a significant role in this. It helps combat UTIs, and this means lesser need to use antibiotics or to misuse or overuse the medicine.  

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