Latest In Vitro Fertilization Discovery Could Boost Success Rates By 50%.

(Newswire.net — March 5, 2015) Alicante, Alicante — In the UK, statistically in vitro fertilization (IVF) does have a low success rate, with 75 % of cycles failing to produce a baby, however the The Daily Mail has just recently released a report stating that researchers have now discovered the molecular switch involved in the process that stops an embryo from being accepted in the mother’s womb, who say that this switch could be blocked with the use of drugs, assisting to improve IVF success rates. IVF or in vitro fertilization is presently the only hope for lots of women wanting to have a baby, with some 50,000 undergoing the treatment every year in the UK, though despite its appeal, the procedure does have a low success rate, with 75 percent of IVF cycles failing to produce a child.

The report states that Manchester University scientists now believe they have found a method to reduce the failure rate by half, revealing the discovery of the ‘molecular switch’ which stops an embryo from being accepted in the mother’s womb. According to the report, if that switch can be blocked with drugs, it could potentially boost the amount of infants born utilizing IVF by up to 18,000 a year. Current figures reveal that about 37 percent of IVF cycles are believed to fail because the embryo does not implant into the wall of the uterus, while women who consistently suffer this failure have been shown to have high levels of a molecular switch, which conflicts in the communication among the embryo and the womb.

In laboratory tests, the scientists found that if they lowered levels of the particle, called microRNA-145, the embryo was not so likely to be rejected. Research study leader Professor John Aplin, whose work is published in the Journal of Cell Science, said… “When an embryo is ready for implantation, its replacement is carefully timed to coincide with the window of optimum receptivity in the uterus.”

Professor Aplin’s team found that a protein called IGF1R is needed during the four-day window for the embryo to adhere to the uterus, with their tests suggesting that the microRNA-145 molecular switch does stop the vital protein from growing during that window.

According to the report, there are already chemicals on the market which have been shown to block microRNAs, and those could be formed to stop this molecular switch from conflicting in the IVF process. “There are lots of ways in which we can hinder microRNAs in the lab,” said Dr Karen Forbes, saying that eventually drugs could be created to enhance implantation rates. Professor Aplin also said… “This is among the hardest groups of women to treat in fertility science, and IVF success rates are still very low across the board.

Repeated IVF cycles are difficult, and can be costly too. Also, a better understanding of the mechanisms which regulate success or failure will eventually lead directly to treatments to make IVF cycles more reliable, so that infertile couples can start their family.”

More information regarding IVF success rates, results, and statistics can be seen on the IVF-Spain website, who claim to have the one of the highest IVF success rates throughout Europe, with many testimonials seen, coming from UK couples who took the decision to undergo IVF treatment abroad.

 

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