A Study Highlights New Techniques in Battling UTIs

(Newswire.net — February 28, 2022) Orlando, FL — The scientific community has been carrying out studies to investigate the remedies helpful in fighting urinary tract infections (UTIs). 

Researchers at Baylor College of Medicine and Washington University School of Medicine have found that the sequence of events that occur during UTI sustains a delicate balance between the responses directed at getting rid of the bacteria and those reducing tissue damage that may occur in the process.

The findings of this interesting study were published in the Cell Reports journal.

The NRF2 pathway was highlighted as a key contributor to such a balance, by regulating both the damage to tissues that can potentially happen and the elimination of bacteria.

It is worth noting that in an animal model of UTI, the use of UTI with the FDA-approved, anti-inflammatory drug dimethyl fumarate (DMF), a known NRF2 activator, lessened tissue damage, and bacterial burden.

It opened the possibility that DMF could be utilized in managing this condition in the future.

The findings of this interesting research could be seen in the journal Cell Reports.

“Urinary tract infections are not only common but typically recurrent and tend to give rise to antibiotic-resistant bacteria, a serious medical concern,” said corresponding author Dr. Indira Mysorekar, E. L. Wagner Endowed Professor of Medicine- infectious diseases at Baylor, previously at Washington University School of Medicine.

“More than 85 percent of UTIs are caused by uropathogenic E. coli (UPEC), bacteria that can attach to the surface of the epithelial cells lining the inside of the bladder, called urothelial cells,” said first author Dr. Chetanchandra S. Joshi, a postdoctoral associate in the Mysorekar lab. 

“Attached UPEC can then enter the urothelial cells, where they reproduce. In the current study, we looked at how urothelial cells fight back UPEC invasion and proliferation while preserving their integrity, which is essential for proper bladder function.”

Urinary tract infections continue to affect more and more people today, and as the rates of this infection continue to increase so does the need for antibiotics.

The good news is that certain all-natural remedies like D-mannose are found to be particularly beneficial for individuals with the infection. This natural healing remedy has long been studied due to its remarkable UTI-fighting benefits.

D-mannose works in binding with E.coli and eliminating the bacteria out of the body. There are many UTI sufferers who resort to its use as a safer alternative to antibiotics. 

To benefit from its use, it is wise to take into account extra-strength supplements like Divine Bounty D-mannose. (https://www.amazon.com/D-Mannose-600mg-Cranberry-Dandelion-Extract/dp/B01LX5KGF0)