Scientists Highlight Technique To Enhance Antibiotic Efficiency

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(Newswire.net — November 3, 2022) Orlando, FL — Today, scientists are increasingly warning against superbugs or the rapidly growing public health issue called antibiotic resistance. 

A multi-disciplinary project carried out by EMBL Australia researchers at Monash University and Harvard University has shown a technique to increase the efficiency of antibiotics against antibiotic-resistant bacteria — also known as superbugs.

According to the World Health Organization, antimicrobial resistance to superbugs has been evolving. It is further worth being warned that it is one of the top 10 global public health threats facing humanity.

The findings of this interesting study were published in Nature Communications.

It provides a pathway to increase the effectiveness of antibiotics, without the need for clinicians to resort to risky strategies of providing higher doses to patients or relying on the discovery of new types of antibiotics.

It is worth noting that during a bacterial infection, the body utilizes molecules known as chemoattractants in recruiting neutrophils to the site of the infection. It is worth keeping in mind that neutrophils are immune cells that have the ability to encapsulate and kill dangerous bacteria, critical to the immune response. 

In this research, the investigators attached a chemoattractant to an antibiotic, and this enabled them to improve the recruitment of immune cells and improve their killing ability.

“When looking at how our immune system can fight bacteria there are two important aspects we look at. The first is our ability to entrap bacterial cells and kill them. The second is the signals — the chemoattractants — calling for more neutrophils, white blood cells which lead the immune system’s response to resolve infection,” said Dr. Jennifer Payne.

Dr. Payne is the lead researcher from EMBL Australia and the Monash Biomedicine Discovery Institute.

“We’ve been working on using dual-function antibiotic-chemoattractant ‘hybrids’, which improve the recruitment of neutrophils and increase the engulfing and killing of the bacteria,” said Dr. Payne.

One of the techniques in fighting antibiotic resistance is to lessen the risk of urinary tract infections, which are often treated with antibiotics. There are plant-based remedies like D-mannose that are being studied due to their UTI-fighting effects.  

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