Human Reproduction Changes On Horizon

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( — February 22, 2015) Alicante, Alicante — IVF technology advances have actually reached a new level, with the UK’s parliament deciding fiercely in favour of brand-new laws in the nation to enable the production of IVF embryos with mitochondrial DNA from a 3rd benefactor, so in addition to the nuclear DNA originating from an embryo’s two parents, a small amount of DNA would additionally originate from a 3rd parent. The brand-new approach will enable couples to make use of IVF for the conception of children, who otherwise would have inherited devastating mitochondrial or other genetic diseases.


MedicalNewsToday has recently released a short article revealing how genetic scientists have made use of a brand-new method that enables the whole genome of IVF embryos to be scanned via the cells of 10 biopsies. The researchers state the screening is the first to be able to spot all the new genetic mutations that occur distinctively in an individual, instead of only those that have actually been passed on from parents. The development makes it possible for the whole genetic code to be scanned for “possibly dangerous” mutations, though more work is required to fathom the precise disease effects, according to the Genome Research Journal, who have also confirmed that the whole-genome sequencing outcomes were analysed from cell biopsies removed from two individual embryos from the same couple.


According to the human reproduction changes study, the strategy indicates that 5-day-old blastocyst-stage embryos have been scanned, first for “de novo mutations,” those occurring spontaneously in the egg or sperm and not passed down from either parent. This, the authors state, increases the power of whole-genome testing to discover the conditions that might befall test-tube babies. Dr. Brock Peters and Dr. Radoje Drmanac, from Complete Genomics, the company based in Mountain View, CA, which has developed the screening innovation, are amongst the study authors, who say… “This is the very first demonstration that a large bulk of single-base de novo mutations, which trigger a disproportionally high percentage of genetic defects, can be discovered in pre-implantation genetic diagnosis.”


In contrast, the report says, the pre-implantation genetic medical diagnosis that is utilized in fertility centres can discover only the big chromosomal abnormalities or genetic mutations that are passed on to in vitro-fertilized (IVF) embryos by their parents. Making use of only 10 cells to do the whole-genome sequencing indicates the DNA has to be magnified, which can introduce errors, according to the research study results, nevertheless, Drs. Peters and Drmanac, working with other commercial researchers from Complete Genomics and from Reprogenetics, did use the method at the NYU Fertility Centre to remove any wrongly determined genetic mutations.


The authors conclude their paper by stating their results suggest that whole-genome sequencing utilizing bar-coded DNA could be made use of in the future as part of the pre-implantation genetic medical diagnosis procedure to help in identifying disease-causing mutations, and reduce the occurrence of genetic diseases. It has recently been announced that for the second time since 2013, the World Congress of Human Reproduction has entrusted the IVF-Spain Foundation to organize a satellite event on genetic technologies applied to fertility.


World class speakers will be unveiling their latest works, such as Professor Nathan Treff, Director of Molecular Biology Research in Gynaecology and Obstetrics at the Robert Wood Johnson Medical School, Santiago Munna, pioneer of pre-implementation genetic screening and preconception screening, as well as Professor Jose Horcajadas, world expert in endometrial receptivity. The human reproduction changes satellite event will be held in Berlin, from the 18th of March until the 21st of March, 2015. More information about current IVF treatments, risks, and success rates can be seen here: IVF Abroad







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