Scientists Warn Carbohydrate-Binding Protein Promotes Inflammation

(Newswire.net — December 27, 2022) Orlando, FL — There are many people around the globe today who are living a reduced quality of life due to conditions like osteoarthritis. On a global scale, this incurable and painful condition has been found to affect more than 7 percent of the population.

Scientists now warn that carbohydrate-binding protein actually promotes inflammation. Today, more and more people particularly the older ones are suffering from osteoarthritis. This condition primarily affects the hip, knee, and spine joints. 

In earlier studies, scientists at MedUni Vienna Department of Orthopaedics have demonstrated that in osteoarthritis patients, there are heightened levels of certain proteins, so-called galectins, and their docking sites.

A recently published study carried out by MedUni Vienna researchers has been able to identify the function of galectin-1 for the first time. Further, they were able to establish that the carbohydrate-binding protein has the ability to control inflammation in the affected cartilage. 

The findings of this research were published in the Journal of Immunology. 

This outstanding study was also featured as a “Research Highlight” in the leading journal Nature Reviews Rheumatology.

“For the very first time our study showed that galectin-1 triggers inflammation rather than the inflammation triggering the secretion of this protein,” explains Stefan Tögel.

Tögel is concerned with the glycobiology of orthopedic diseases at the University Department of Orthopaedics. 

It is worth noting that Galetcin-1 is a carbohydrate-binding protein in humans. In osteoarthritis, such a protein is over-expressed in the joint cartilage. Experts warn that the worse the degeneration of the joint, the more of it is secreted. 

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