Turmeric Believed to Sensitize Ovarian Cancer Cells to Therapies

(Newswire.net — August 5, 2019) Orlando, FL — Ovarian cancer affects many women today. While there are treatments available, they do not work for everyone. The good news is that certain natural remedies have been found to enhance the efficacy of treatments.

Turmeric is believed to sensitize ovarian cancer cells to chemotherapy and radiotherapy. It is important to understand that the hurdle of these treatments is the heterogeneity of ovarian tumors.

This means that not all types of tumor tissues respond equally to a particular drug. Further, this response actually varies from one person to another.

According to experts, there is a reduction of the sensitivity of these therapies through the action of pro-survival molecules in the cancer cells. To fight this problem, it is important to make the ovarian cancer cells sensitive to these therapies.

One way to do this is to use curcumin, which is a phytochemical that can be found in turmeric. Curcumin is widely studied by researchers and clinicians due to the variety of therapeutic agents it contains.

It has genoprotective, antifungal, anti-inflammatory, antibacterial, anticarcinogenic, antiproliferative,antibiotic, antimicrobial, anti-purulent, immunomodulating, anticatabolic,neurorestorative, and metal-chelating properties.

Curcumin even contains antiviral, renoprotective, anticoagulant, insulin-sensitizing, androgenic, antifibrotic, antiseptic, antioxidant,anti-amyloidogenic, and anti-cytotoxic agents.

Experts have found that curcumin can increase the sensitivity of pharmaceutical drugs that are platinum-based. These medications are often used in the treatment of various cancers, which includes one affecting the ovary

What makes it even more interesting is that it could potentially decrease the expression of a variety of factors like NF-kappa B. This has been found to significantly help induce apoptosis.

In a study, it was discovered that the use of curcumin 6 hours prior to chemotherapy or radiotherapy resulted in some improvements. It was able to enhance the sensitivity of ovarian cancer cells to treatments like chemotherapy and radiotherapy.

The researchers found that the activity of curcumin was due to its ability to down-regulate pro-survival proteins, which includes Bcl and Mcl-1. This led to an increase in apoptosis or cell death even when the doses of chemotherapeutic drug were low.

The study researchers suggest that turmeric administration can improve the sensitivity of ovarian cancer cells to radiotherapy or chemotherapy. This could significantly improve the effects of both treatments.

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