A Study Shows Histamine Plays Potential Role in Depression

(Newswire.net — March 24, 2022) Orlando, FL — Scientists have been carrying out research studies to find some effective remedies for mental health issues like depression. Since the pandemic hit, the rates of depression and anxiety have been found to increase.

A study involving mouse subjects has shown that histamine could be a key player in depression.  

This study was carried out by researchers at Imperial College London and the University of South Carolina.

Its findings add to increasing evidence suggesting that inflammation, and the accompanying release of the molecule histamine, impact a key molecule responsible for mood in the brain — serotonin.

Human research has identified histamine as a new molecule of interest in depression. Such findings of this recent study could pave way for the development of depression treatment. 

According to experts, inflammation triggers the release of histamine in the body. It increases blood flow to the areas affected and this floods them with immune cells. While it is true that these effects aid in battling infections, both long-term and acute inflammation is increasingly associated with depression. 

It is worth noting that inflammation may be accompanied by infections, but can also be caused by allergic responses, stress, and a host of chronic diseases such as cancer, diabetes, obesity, and neurodegenerative diseases.

“Inflammation could play a huge role in depression, and there is already strong evidence that patients with both depression and severe inflammation are the ones most likely not to respond to antidepressants,” said Lead author Dr. Parastoo Hashemi, from Imperial’s Department of Bioengineering.

“Our work shines a spotlight on histamine as a potential key player in depression. This, and its interactions with the ‘feel-good molecule’ serotonin, may thus be a crucial new avenue in improving serotonin-based treatments for depression.”

More studies are still underway to look into the various aspects of depression. Today, there are many scientists who are carrying out research to investigate the best possible ways to combat depression.

One of the most important things to keep in mind is that this mental health issue may be preventable. There are factors found to contribute to the increased risk of this disease, such as diet.

Consumption of foods loaded with toxins and chemicals, which have brain-altering effects, may increase the risk of this condition. Toxin buildup has long been linked with a myriad of undesirable health outcomes.

It is best to avoid or reduce intake of unhealthy food and have a body detox, which may lessen the body’s toxic burden. This may be made through the use of formulas like Divine Bounty Activated Charcoal (https://www.amazon.com/Organic-Activated-Charcoal-Capsules-Whitening/dp/B071NZ5G56).